From its single proprietary manufacturing process which mimics the embryonic environment, Histogen produces three key products: 1) a soluble multipotent cell conditioned media (CCM) used for skin care and hair growth applications, 2) a soluble low molecular weight sub-fraction for oncology applications (105F), and 3) insoluble extracellular matrix (ECM) for orthopedics and wound care
Cell Conditioned Media (CCM)
The liquid complex produced through Histogen’s manufacturing process contains soluble biologicals with a diverse range of embryonic-like proteins. Because the cells produce and secrete these factors while developing the ECM, these proteins are naturally infused into the liquid media in a stabilized form. The CCM contains a diverse mixture of cell-signaling materials, including human growth factors such as Keratinocyte Growth Factor, soluble human ECM proteins such as collagen, and embryonic proteins which support the epidermal stem cells that renew skin throughout life. The naturally stabilized and bioactive CCM holds potential for a spectrum of applications in therapeutics and aesthetics.
Extracellular Matrix (ECM)
The ECM produced through Histogen’s proprietary process is a unique, all-human, naturally-secreted material. It is most similar to early embryonic structural tissue which provides the framework and signals necessary for cell in-growth and tissue development. By producing similar ECM materials to those that aided in the original formation of these tissues in the embryo, regenerative cells are supported both in vitro and potentially as therapeutics in vivo. In addition to orthopedic uses including as a scaffold for the support of bone and cartilage growth and critical defect repair, this ECM holds therapeutic potential in areas such as tissue regeneration patches for surgical applications, wound healing, and coatings for medical devices.
Low Molecular Weight Sub-Fraction (105F)
105F is generated from the collection of CCM during medium changes in the last four weeks of Histogen’s cell culture process. Material below 10K molecular weight is again filtered using 5K molecular weight spin filters. This low molecular weight sub-fraction contains unique naturally-secreted peptides shown to trigger cancer cell death through multiple pathways.